Highlighted publications

  1. Deng L, and Chiu IM. Neuroimmune interactions in itch. In Dong X, Kim BS, and Follansbee T (Ed.), The Itch Spectrum (2026)
    Book chapter

  2. Deng L, Gillis JE, Chiu IM, Kaplan DH. Sensory neurons: an integrated component of innate immunity. Immunity (2024)
    Article

  3. Deng L, Costa F, Blake KJ, Choi S, Chandrabalan A, Yousuf MS, Shiers S, Dubreuil D, Vega-Mendoza D, Rolland C, Deraison C, Voisin T, Bagood MD, Wesemann L, Frey AM, Palumbo JS, Wainger BJ, Gallo RL, Leyva-Castillo JM, Vergnolle N, Price TJ, Ramachandran R, Horswill AR, Chiu IM. S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis. Cell (2023)
    Article
    Commentary: Cell (Article) | Harvard News and Research (Video) | Smithsonian Magazine (Article) | NPR (Article, Audio) | The Boston Globe (Article) | BBC (Article) | NBS News (Article) | ASM TWiM podcast (Audio)

  4. Deng L, Chiu IM. A neuropeptide regulates immunity across species. Neuron (2022)
    Article

  5. Deng L, Chiu IM. Microbes and Pain. PLoS Pathog (2021)
    Article

  6. Deng L, Schilcher K, Burcham LR, Kwiecinski JM, Johnson PM, Head SR, Heinrichs DE, Horswill AR, Doran KS. Identification of key determinants of Staphylococcus aureus vaginal colonization. mBio (2019)
    Article

  7. Deng L, Spencer BL, Holmes JA, Mu R, Rego S, Weston TA, Hu Y, Sanches GF, Yoon S, Park N, Nagao PE, Jenkinson HF, Thornton JA, Seo KS, Nobbs AH, Doran KS. The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the pathogenesis of meningitis. PLoS Pathog (2019)
    Article

  8. Deng L, Mu R, Weston TA, Spencer BL, Liles R, Doran KS. Characterization of a two-component system transcriptional regulator LtdR that impacts Group B Streptococcal colonization and disease. Infect Immun (2018)
    Article

  9. #Feng Y, #Ma X, #Deng L, Yao B, Xiong Y, Wu Y, Wang L, Ma Q, Ma F. Role of selectins and their ligands in the human implantation state. Glycobiology (2017) #these authors contributed equally
    Article

Other publications

  1. Chung EN, Lee J, Polonio CM, Choi J, Faust Akl C, Kilian M, Weiß WM, Gunner G, Ye M, Hyun Heo T, Drake SS, Yang L, d’Eca CRGL, Lee JH, Deng L, Farrenkopf D, Schule AM, Lee HG, Afolabi O, Ghaznavi S, Smirnakis SM, Chiu IM, Kuchroo VK, Quintana FJ, Wheeler MA. Psychedelic control of neuroimmune interactions governing fear. Nature (2025)

  2. Xie Z, Rose L, Feng J, Zhao Y, Lu Y, Kane H, Hibberd TJ, Hu X, Wang Z, Zang K, Yang X, Richardson Q, Othman R, Venezia O, Zhakyp A, Gao F, Abe N, Vigeland K, Wang H, Branch C, Duizer C, Deng L, Meng X, Zamidar L, Hauptschein M, Bergin R, Dong X, Chiu IM, Kim BS, Spencer NJ, Hu H, Jackson R. Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force. Cell (2025)

  3. Hou Y, Sun L, LaFleur MW, Huang L, Lambde C, Thakore PI, Geiger-Schuller K, Kimura K, Yan L, Zang U, Tang R, Shi J, Barilla R, Deng L, Subramanian A, Wallrapp A, Choi HS, Kye Y, Ashenberg O, Schiebinger G, Doench JG, Chiu IM, Regev A, Sharpe AH, Kuchroo VK. Neuropeptide signaling orchestrates T cell differentiation. Nature (2024)

  4. Xu H, Lotfy P, Gelb S, Pragana A, Hehnly C, Shipley FB, Zawadzki ME, Cui J, Deng L, Taylor M, Webb M, Lidov HGW, Andermann ML, Chiu IM, Ordovas-Montanes J, Lehtinen MK. A collaboration between immune cells and the choroid plexus epithelium in brain inflammation. Cell (2024

  5. Leyva-Castillo JM, Vega-Mendoza D, Strakosha M, Deng L, Choi S, Miyake K, Karasuyama H, Chiu IM, Phipatanakul W, Geha RS. Basophils are important for the development of allergic skin inflammation. J Allergy Clin Immunol (2024)

  6. Key FM, Khadka VD, Romo-González C, Blake KJ, Deng L, Lynn TC, Lee JC, Chiu IM, García-Romero MT, Lieberman TD. On-person adaptive evolution of Staphylococcus aureus during treatment for atopic dermatitis. Cell Host Microbe (2023)

  7. Pinho-Ribeiro FA, Deng L, Neel DV, Erdogan O, Basu H, Yang D, Choi S, Walker AJ, Carneiro-Nascimento S, He K, Wu G, Stevens B, Doran KS, Levy D, Chiu IM. Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion. Nature (2023)

  8. Enamorado M, Kulalert W, Han SJ, Rao I, Delaleu J, Link VM, Yong D, Smelkinson M, Gil L, Nakajima S, Linehan JL, Bouladoux N, Wlaschin J, Kabat J, Kamenyeva O, Deng L, Gribonika I, Chesler AT, Chiu IM, Le Pichon CE, Belkaid Y. Immunity to the microbiota promotes sensory neuron regeneration. Cell (2023)

  9. Staurengo-Ferrari L, Deng L, Chiu IM. Interactions between nociceptor sensory neurons and microbial pathogens in pain. Pain (2022)

  10. Yang D, Jacobson A, Meerschaert KA, Sifakis JJ, Wu Meng, Chen X, Yang T, Zhou Y, Vikas Anekal P, Rucker RA, Sharma D, Sontheimer-Phelps A, Wu GS, Deng L, Anderson MD, Choi S, Neel D, Lee N, Kasper DL, Jubri B, Huh JR, Hohansson M, Thiagaraph JR, Riesenfeld SJ, Chiu IM. Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protections. Cell (2022)

  11. Yang NJ, Neel DV, Deng L, Heyang M, Kennedy-Curran A, Tong VS, Park JM, Chiu IM. Nociceptive sensory neurons mediate inflammation induced by edema toxin. Front Immunol (2021)

  12. van Sorge NM, Bonsor DA, Deng L, Lindahl E, Schmitt V, Lyndin M, Schmidt A, Nilsson OR, Brizuela J, Boero E, Sundberg EJ, van Strijp JAG, Doran KS, Singer BB, Lindahl G, McCarthy AJ. Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors. EMBO J (2021)

  13. Burcham LR, Le Breton Y, Radin JN, Spencer BL, Deng L, Hiron A, Ransom MR, Mendonça JDC, Belew AT, El-Sayed NM, McIver KS, Kehl-Fie TE, Doran KS. Identification of zinc-dependent mechanisms used by Group B Streptococcus to overcome calprotectin-mediated stress. mBio (2020)

  14. Campeau A, Mills RH, Blanchette M, Bajc K, Malfavon M, Munji RN, Deng L, Hancock B, Patras KA, Olson J, Nizet V, Daneman R, Doran KS, Gonzalez DJ. Multidimensional proteome profiling of blood-brain barrier perturbation by Group B Streptococcus. mSystems (2020)

  15. Kim BJ, McDonagh MA, Deng L, Gastfriend BD, Schubert-Unkmeir A, Doran KS, Shusta EV. Streptococcus agalactiae disrupts P-glycoprotein function in endothelial cells. Fluids Barriers CNS (2019)

  16. Spencer BL, Deng L, Patras KA, Burcham ZM, Sanches GF, Nagao PE, Doran KS. Cas9 contributes to Group B streptococcal colonization and disease. Front Microbiol (2019)

  17. Ma F, Deng L, Secrest P, Shi L, Zhao J, Gagneux P. A mouse model for dietary xenosialitis: antibodies to xenoglycan can reduce fertility. J Biol Chem (2016)

  18. Fong JJ, Sreedhara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A. Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14. EMBO J, 34(22)2775-88 (2015)

  19. Laubli H, Silva FA, Stanczak MA, Siddiqui SS, Deng L, Verhagen A, Varki NM, Varki A. Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. J Biol Chem (2014)

  20. Gordts PL, Foley EM, Lawrence R, Sinha R, Lameda-Diaz C, Deng L, Nock R, Glass CK, Erbilgin A, Lusis AJ, Witztum JL, Esko JD. Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling. Cell Metab (2014)

  21. Laubli H, Pearce OMT, Schwarz F, Siddique SS, Deng L, Stanczak MA, Deng L, Verhagen A, Secrest P, Lusk C, Schwarz AG, Varki NM, Bui JD, Varki A. Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer. Proc Natl Acad Sci (2014)

  22. Ma F, Wu D, Deng L, Secrest P, Zhao J, Varki NM, Lindheim S, Gagneux P. Sialidases on mammalian sperm mediate deciduous sialylation during capacitation. J Biol Chem (2012)

  23. Wang X, Mitra N, Cruz P, Deng L, DISC Comparative Sequencing Program, Varki NM, Angata T, Green E, Mullikin J, Hayakawa T, Varki A. Evolution of Siglec-11 and Siglec-16 genes in hominins. Mol Biol Evol, 29(8):2073-86 (2012)

  24. Wang X, Chow R, Deng L, Anderson D, Weidner N, Goldwin AK, Bewtra C, Zlotnik A, Bui JD, Varki A, Varki NM. Expression of Siglec-11 by human and chimpanzee ovarian stromal cells with uniquely human ligands: implications for human ovarian physiology and pathology. Glycobiology, 21(8):1038-48 (2011)